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KMID : 0613820080180111479
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Journal of Life Science
2008 Volume.18 No. 11 p.1479 ~ p.1484
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Promotion of Synaptic Maturation by Deep Seawater in Cultured Rat Hippocampal Neurons
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Kim Seong-Ho
Lee Hyun-Sook
Nam Kyung-Soo
Shon Yun-Hee
Moon Il-Soo
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Abstract
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Deep seawater (DSW) refers to water extracted from the ocean, usually at depths of 200 meters or more, which is rich in inorganic materials and has attracted attention for various applications. We investigated the effects of the DSW on the synaptic maturation of cultured rat hippocampal neurons. Immunocytochemical examination of DIV21 showed that PSD-95, αCaMKII, and synGAPα1 clusters were strengthened and coupling rates of SV2 and NR2B were significantly increased in neurons grown in the presence of H-800 and H-1000 DSW. Our results indicate that DSW promotes the formation of excitatory postsynaptic signal transduction complexes NRC/MASC and functional synapses.
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KEYWORD
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CaMKII, deep seawater, hippocampal neuron, NR2B, SV2, synapse, synGAPα1
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